Dendritic cells (DC) are postulated to play a role in autoimmune diseases such as Systemic Lupus Erythematosus (SLE).We reported a 13-year-old female SLE patient who presents with chronic arthritis accompanied by persistent fever, dyspnea, sleep disturbance, headache, stomatitis, rash, and muscle weakness.The supporting examinations showed abnormal
AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway
Abstract Background Glioblastoma (GBM) is the most common brain tumor with the worst prognosis.Temozolomide is the only first-line drug for GBM.Unfortunately, the resistance issue is a classic problem.Therefore, it is essential to develop new drugs to treat GBM.As an oncogene, Skp2 is involved in the pathogenesis of various cancers including GBM.In
German Gymnastics Association (Deutsche Turnerschaft) in Relation to Sport Movement in Germany before the World War I
Modern physical culture was one of the many important processes that have taken over the political, social, and cultural life in Germany in the second half of the 19th century.At the turn of the 19th century in Germany, two big middle-class organizations have been formed to deal with physical activity affairs: the German Gymnastics Association (Deu
Is lysate-based human leukocyte antigen crossmatch a reliable method to contraindicate a transplant?
The presence of preformed cytotoxic donor-specific antibodies (DSAs) has been associated with inferior allograft outcomes in the immediate posttransplant period.Since the 1970s, the primary method for determining the presence of DSAs has been the complement-dependent cytotoxicity crossmatch.Solid phase assays on the Luminex platform were introduced